Recently Discovered T Cell Subsets Cannot Keep Their Commitments

Recently discovered T cell subsets cannot keep their commitments.

After activation by antigen/MHC (signal 1) and CD28-dependent co-stimulation (signal 2), resting CD4(+) T cells commit to one of a variety of functionally and molecularly defined phenotypes. Two long established CD4 phenotypes, Th1 and Th2 cells, have been regarded as terminally differentiated formats. Recently, two additional phenotypes, tissue-protective regulatory (Tregs) and tissue-destruct...

Regulatory T Cell Subsets in Filarial Infection and Their Function

Filarial infections in humans are chronic infections that cause significant morbidity. The chronic nature of these infections with continuous antigen release is associated with a parasite-specific T cell hypo-responsiveness that may over time also affect the immune responses to bystander antigens. Previous studies have shown the filarial parasite antigen-specific T cells hypo-responsiveness is ...

The regulatory T cell family: distinct subsets and their interrelations.

Recently Discovered Pulsars and Unidentified Egret Sources

We present a correlative study between all unidentified EGRET sources at low Galactic latitudes and the newly discovered pulsars in the released portion of the Parkes multibeam radio survey. We note 14 positional coincidences: eight of these are “Vela-like” pulsars, with relatively small periods, small characteristic ages, and high spin-down luminosities. Three of these coincidences have been i...

Abundances of Recently Discovered Planetary Nebulae

In this work we report spectrophotometric observations of a planetary nebula sample towards the galac-tic bulge. A total of 45 PNe was observed and their physical parameters (electron density and temperature) were derived. Ionic abundances were calculated using a three-level atom model and abundances were derived through ionisation correction factors. Results show low abundance objects at high ...